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Dietary questionnaires were conveyed to the HPFS participants In 1986, 1990, 1994, and 1998 and to the NHS participants in 1980, 1984, 1986, 1990, 1994, and 1998. On for each one questionnaire, participants were asked how often on average during the previous golden ratio coffee pour over year they had consumed java and tea. The participants could choose from 9 responses. The method acting of java preparation was assessed only when In 1990 atomic number 49 some studies. Decaffeinated java and unusual types of caffeinated soft drinks were number 1 assessed indium 1986 In the HPFS and atomic number 49 1984 atomic number 49 the NHS. In addition, we too inquired atomic number 49 the NHS questionnaire of 1980 whether the participant’s expenditure for each drinkable had greatly enlarged or minimized o'er the past 10 years. Using the US Department of Agriculture solid food composition sources, supplemented with other sources, we estimated that the caffeine content was 137 mg per transfuse of coffee, 47 milligram per transfuse of tea, 46 milligram per can Oregon feeding bottle of dope potable, and 7 mg per service of process of chocolate sugarcoat. We assessed the sum intake of caffein past summing the caffein content for a particular amount of from each one food during the previous year (1 transfuse for java Beaver State tea leaf, 1 12-apothecaries' ounce nursing bottle Oregon can for effervescent beverages, and 1 troy ounce for chocolate) increased past A weight relative to the frequency of its employ. In our validation study, we obtained high correlations between expenditure of coffee and other caffeinated beverages estimated from the solid food frequency questionnaire and consumption estimated from recurrent 1-week diet records (coffee, r=0.78; tea leaf, r=0.93; and caffeinated sodas, r=0.85). 18

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